At day 2, the patches were removed, and 1 photopatch test series was irradiated with uva 5 jcm 2. Octocrylenes ability to cause contact allergy is probably attributable to its reactivity towards lysine. Physical blockers include ingredients zinc oxide and titanium dioxide. New insights into methylisothiazolinones and octocrylene contact. Conclusions octocrylene appears to be a strong allergen leading to contact. Octocrylene, an emerging photoallergen allergy and. We report and discuss 50 cases of photoallergic contact dermatitis from octocrylene use andor positive photopatch test reactions to this uv filter and draw. Six cases of pacd were published between 2003 and 2006 68 3 children with severe allergic contact dermatitis, one of them after passive transfer, 7 who strongly reacted to patch tests with octocrylene, and 3 adults who had pacd and strongly reacted to photopatch tests with octocrylene. Octocrylene, an emerging photoallergen allergy and clinical. Contact allergy to octocrylene contact allergy to octocrylene carrotte. Octocrylene is an ultraviolet uvb and uvaii absorber that was introduced some 15 years ago, and is now widely used in sunscreen agents and skin care cosmetics.
Common examples include the reactions on sunexposed skin to furocouma. Lefebvre, i bonnevalle, a segard, m delaporte, e thomas, p. Occupational dermatology research and education centre, australia. We report 23 cases of positive test reactions to octocrylene 5 patch test and 18 photopatch. However, they did not report any history of skin reactions from sunscreen products. Authoritative facts about the skin from dermnet new zealand.
Muller, moosinning, germany filtered with a schott wg 305 filter 1 mm schott, clichy, france and a. Contact dermatitis is an itchy, blistering skin rash typically caused by. Two of them had also a history of pacd from ketoprofen. Patients who have positive photopatch test reactions to ketoprofen often show co. Review of the safety of octocrylene used as an ultraviolet. Octocrylene, an emerging photo allergen used as a uv filter in sunscreens.
Contact allergy to octocrylene also occurs, but is far less frequent, and is seen, in most cases, in children, resulting from the use of octocrylene containing sunscreen products. The clinical studies show that octocrylene is both a photocontact allergen and a contact allergen. Most allergic reactions arise from the other chemicals avobenzone has been formulated with to make it more photostable. Patch testing using finn chambers on scanpor tape was performed to the. People are becoming more aware of the skin cancer risks with sun exposure. Avobenzone allergy is diagnosed by performing specific patch tests and photopatch tests. Contrary to contact allergy, photoallergic contact dermatitis to octocrylene is much more frequent in adults than in children, in whom very few cases have been reported. Contact allergy to octocrylene in sunscreen with recurrence from. Your patch testing results indicate that you have a contact allergy to octocrylene. Octocrylene s ability to cause contact allergy is probably attributable to its reactivity towards lysine. Regarding contact allergy attributed to octocrylene, some case reports and positive patch test studies in both adults and children can be found in the scientific literature.